Interesting paper from Patel et al and the Maudsley that highlights the risks of antidepressant pharmacotherapy with traditional antidepressants for those patients presenting with unipolar depression but who would seem to actually have a diathesis for bipolar disorder. The analysis of cohort data found that the use of traditional antidepressant medication increased the risk of a manic episode in a depressed patient group. To me, this highlights the importance of both systematic screening for bipolar disorder and the importance of careful monitoring during antidepressant therapy. The paper is available here.