Can you help with our research aimed at validating two new scales to measure mood and anxiety symptoms? The goal is to involve as broad an age range (from 18 upwards) as possible, equal representation of males and females, and people from different cultural and educational backgrounds. The title of the study is: Pilot observational […]
The UK National Institute of Clinical Excellence issued a statement on alcohol use in response to the Department of Health new proposed guidance on alcohol use. Both make interesting reading. The bottom line as already widely publicized, is that men should drink no more than 14 units of alcohol per week, and pregnant women should […]
A study published online and available here in October by Roberge et al showed quite clearly that the diagnosis of Generalized Anxiety Disorder (GAD) is often missed by clinicians, but that when identified or when co-morbid with depression, doctors often treat the condition appropriately. Both psychological treatments such as cognitive therapy and other psychotherapies and […]
In a paper in JAMA Psychiatry available here, Luby et al reported the results of their investigation of the relationship between childhood depression and grey matter development in a cohort of young depressed children. They concluded that study demonstrated “an association between early childhood depression and the trajectory of cortical gray matter development in late […]
Interesting paper from Patel et al and the Maudsley that highlights the risks of antidepressant pharmacotherapy with traditional antidepressants for those patients presenting with unipolar depression but who would seem to actually have a diathesis for bipolar disorder. The analysis of cohort data found that the use of traditional antidepressant medication increased the risk of […]
I came across a randomized controlled trial in JAMA Internal Medicine from July this year that tries to examine the relationship between cognition, Mediterranean diet and nuts (available here). It had some positive results but overall it seemed the p values were not that impressive given the multiple testing. However, it reminded me of a […]
There were a few articles of interest that I came across this week on PTSD. THe first was a study by Deng et al looking at PTSD in patients with adult congenital heart disease. They found very high rates of PTSD (11-20%) among this patient group at a tertiary referral centre, and also point out […]
A new and interesting study by Prossin et al throws some light on the role between depression, inflammatory processes in the body and other diseases such as cardiovascular disease.
Interesting study by Tilhonen et al published online and available here on the associations between long term medication use and mortality risk in patients with schizophrenia. It is possible that the results were due to confounding. I look forward to further publications on this topic.
The CEQUEL study just published by Geddes et al from Oxford is a significant contribution to our understanding of how to best treat patients with bipolar depression.