Alcohol misuse


Alcohol use and health

The UK National Institute of Clinical Excellence issued a statement on alcohol use in response to the Department of Health new proposed guidance on alcohol use. Both make interesting reading. The bottom line as already widely publicized, is that men should drink no more than 14 units of alcohol per week, and pregnant women should […]

Child Development and Depression

In a paper in JAMA Psychiatry available here, Luby et al reported the results of their investigation of the relationship between childhood depression and grey matter development in a cohort of young depressed children. They concluded that study demonstrated “an association between early childhood depression and the trajectory of cortical gray matter development in late […]

Antidepressants and mania

Interesting paper from Patel et al and the Maudsley that highlights the risks of antidepressant pharmacotherapy with traditional antidepressants for those patients presenting with unipolar depression but who would seem to actually have a diathesis for bipolar disorder. The analysis of cohort data found that the use of traditional antidepressant medication increased the risk of […]

Mediterranean Diet, Nuts and Mental health

I came across a randomized controlled trial in JAMA Internal Medicine from July this year that tries to examine the relationship between cognition, Mediterranean diet and nuts (available here). It had some positive results but overall it seemed the p values were not that impressive given the multiple testing. However, it reminded me of a […]

Depression and Inflammation

A new and interesting study by Prossin et al throws some light on the role between depression, inflammatory processes in the body and other diseases such as cardiovascular disease.

Meds for Bipolar Depression

The CEQUEL study just published by Geddes et al from Oxford is a significant contribution to our understanding of how to best treat patients with bipolar depression.

Mindfulness, anxiety, depression and cancer

This study by Zhang et al was flagged up by Medscape. This was an interesting meta-analysis as though the abstract reads as positive in some ways, actually the most important measures showed little effect. This study seems to suggest that not all types of mindfulness are effective for long-term symptom remission.

New class of drugs for depression?

A very interesting Phase 1 trial of a potential new drug for major depressive disorder was published in Molecular Psychiatry by Fava et al this week, available here. This study used a novel drug that encourages neurogenesis in the hippocampus. This is thought to be the same mechanism that mediates the therapeutic effects of older […]

Lithium maintenance treatment and kidney function

An important paper in the Lancet this month by Clos et al (available here) presents cohort data that shows that kidney function does not seem to be adversely affected by treatment with lithium. This is more important than it sounds as lithium remains the gold standard for maintenance treatment of bipolar affective disorder, a condition […]

Depression in children and screen time

I found a reuters news article that linked to an interesting paper on the association between depression and screen time in children (reuters article and paper both available here.) It seems that very long periods of time every day in front of TV or computer screens are associated with higher risk of depression, but modest […]