In a paper in JAMA Psychiatry available here, Luby et al reported the results of their investigation of the relationship between childhood depression and grey matter development in a cohort of young depressed children. They concluded that study demonstrated “an association between early childhood depression and the trajectory of cortical gray matter development in late school age and early adolescence.” Childhood and adolescent depression is not uncommon, and with difficulty with access to effective treatments such as CBT, and with concerns over the safety and efficacy of SSRIs among children, it can be difficult for parents to know how to help a child with depression.